Publications and Patents

Google Scholar profile of Stephan A. Sieber


Zhao, W., Cross, A.R., Crow-McAuliffe, C., Weigert-Munoz, A., Csatary, E.E., Solinski, A.E., Krysiak, J., Goldberg, J.B., Wilson, D.N., Medina, E., Wuest, W.M., Sieber, S.A., "The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa",
Angew. Chem. Int. Edit., doi

Winnacker, M., Beringer, A.J.G., Gronauer, T.F., Güngör, H.H., Reinschlüssel, L., Rieger, B., Sieber, S.A., "Polyamide/PEG Blends as Biocompatible Biomaterials for the Convenient Regulation of Cell Adhesion and Growth",
Macromol. Rapid Commun., doi

Crane, E.A., Heydenreuter, W., Beck, K.R., Strajhar, P., Vomacka, J., Smiesko, M., Mons, E., Barth, L., Neuburger, M., Vedani, A., Odermatt, A., Sieber, S.A., Gademann, K., "Profiling Withanolide A for Therapeutic Targets in Neurodegenerative Diseases",
Bioorg. Med. Chem., doi

Lakemeyer, M., Bertosin, E., Möller, F., Balogh, D., Strasser, R., Dietz, H., Sieber, S.A., "Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer-hexamer assembly",
Angew. Chem. Int. Edit., doi

De Ford, C., Penchalaiah, K., Kreft, A., Humar, M., Heydenreuter, W., Kangani, M., Sieber, S.A., Tietze, L.F., Merfort, I., "Bifunctional Duocarmycin Analogues as Inhibitors of Protein Tyrosine Kinases",
J. Nat. Prod., doi

Coelho, J., Stahl, M., Blömeke, N., Meighen-Berger, K., Alvira, C.P., Zhang, Z.R., Sieber, S.A., Feige, M., "A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration",
Nat. Commun., doi


Falcón Garcia, C., Stangl, F., Götz, A., Zhao, W., Sieber, S.A., Opitz, M., Lieleg, O., "Topographical alterations render bacterial biofilms susceptible to chemical and mechanical stress",
Biomater. Sci., doi

Koczian, F., Nagło, O., Vomacka, J., Vick, B., Servatius, P., Zisis, T., Hettich, B., Kazmaier, U., Sieber, S.A., Jeremias, I., Zahler, S., Braig, S., "Targeting the ER-mitochondria interface sensitizes leukemia cells towards cytostatics",
Haematologica, doi

Vogele, K., Frank, T., Gasser, L., Goetzfried, M., Hackl. M.W., Sieber, S.A., Simmel, F., Pirzer, T., "Towards synthetic cells using peptide-based reaction compartments",
Nat. Commun., doi

Stahl, M., Korotkov, V.S., Balogh, D., Kick, L.M., Gersch, M., Pahl, A., Kielkowski, P., Richter, K., Schneider, S., Sieber, S.A., "Selective Activation of Human Caseinolytic Protease P (ClpP)",
Angew. Chem. Int. Edit., doi

Fux, A., Korotkov, V.S., Schneider, M., Antes, I., Sieber, S.A., "Chemical cross-linking enables drafting ClpXP proximity maps and taking snapshots of in situ interaction networks",
Cell Chem. Biol., doi

Hoegl, A., Nodwell, M.B., Kirsch, V.C., Bach, N.C., Pfanzelt, M., Stahl, M., Schneider, S., Sieber, S.A., "Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics",
Nat. Chem., doi

Gronauer, T.F., Mandl, M.M., Lakemeyer, M., Hackl, M.W., Meßner, M., Korotkov, V.S., Pachmayr, J., Sieber, S.A., "Design and synthesis of tailored human caseinolytic protease P inhibitors",
Chem. Commun., doi

Drechsel, J., Mandl, F.A., Sieber, S.A., "A chemical probe to monitor the parkinsonism-associated protein DJ-1 in live cells",
ACS Chem. Biol., doi

Lakemeyer, M., Zhao, W., Mandl, F.A., Hammann, P., Sieber, S.A., "Thinking outside the box - novel antibacterials to tackle the resistance crisis",
Angew. Chem. Int. Edit., doi

Giglio, K.M., Keohane, C.E., Stodghill, P.V., Steele, A.D., Fetzer, C., Sieber, S.A., Filiatrault, M.J., Wuest, W.M., "Transcriptomic profiling suggests that Promysalin alters metabolic flux, motility, and iron regulation in Pseudomonas putida KT2440",
ACS Infect. Dis., doi

Hofbauer, B.*, Vomacka, J.*, Stahl, M., Korotkov, V.S., Jennings, M., Wuest, W., Sieber, S.A., "A dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins",
Biochemistry, doi

Keohane, C.E., Steele, A.D., Fetzer, C., Khowsathit, J., van Tyne, D., Moynié, L., Gilmore, M.S., Karanicolas, J., Sieber, S.A., Wuest, W.M., "Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase",
J. Am. Chem. Soc.
, doi


Wright, M.H., Tao, Y., Drechsel, J., Krysiak, J., Chamni, S., Weigert Muñoz, A., Harvey, N., Romo, D., Sieber, S.A., "Quantitative Chemoproteomic Profiling Reveals Multiple Target Interactions of Spongiolactone Derivatives in Leukemia Cells",
Chem. Commun., doi

Lehmann, J., Cheng, T.Y., Aggarwal, A., Park, A.S., Zeiler, E., Raju, R.M., Akopian, T., Kandror, O., Bach, N.C., Sacchettini, J.C., Moody, D.B., Rubin, E.J., Sieber, S.A., "An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis",
Angew. Chem. Int. Edit., doi

Fetzer, C., Korotkov, V.S., Thänert, R., Lee, K.M., Neuenschwander, M., von Kries, J.P., Medina, E., Sieber, S.A., "A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus",
Angew. Chem. Int. Edit., doi

Stahl, M., Sieber, S.A., "An Amino Acid Domino Effect Orchestrates ClpP's Conformational States",
Curr. Opin. Chem. Biol.doi

Stiegler, S.C., Rübbelke, M., Korotkov, V.S., Weiwad, M., John, C., Fischer, G., Sieber, S.A., Sattler, M., Buchner, J., "A chemical compound inhibiting the Aha1-Hsp90 chaperone complex",
J. Biol. Chem.doi

Wright, M.H., Fetzer, C., Sieber, S.A., "Chemical probes unravel an antimicrobial defense response triggered by binding of the human opioid dynorphin to a bacterial sensor kinase",
J. Am. Chem. Soc., doi

Lieleg, O., Werb, M., Falcón García, C., Bach, N.C., Grumbein, S., Sieber, S.A., Opitz, M., "Surface topology affects wetting behavior of Bacillus subtilis biofilms", 
npj Biofilms Microbiomes, doi

Krysiak, J.*, Stahl, M.*, Vomacka, J.*, Fetzer, C., Lakemeyer, M., Fux, A., Sieber, S.A.*, "Quantitative map of beta-lactone induced virulence regulation", 
J. Proteome Res., doi

Rieb, J., Dominelli, B., Mayer, D., Jandl, C., Drechsel, J., Heydenreuter, W., Sieber, S.A., Kühn, F.E., "Influence of wing-tip substituents and reaction conditions on the structure, properties and cytotoxicity of Ag(I)– and Au(I)–bis(NHC) complexes",
Dalton Trans., doi

Zhu, M., Harshbarger, W., Robles, O., Krysiak, J., Hull, K., Cho, S.W., Richardson, R., Yang, Y., Garcia, A., Spiegelman, L., Ramirez, B., Wilson, C., Yau, J.A., Moore, J., Walker, C., Sacchettini, J., Liu, W., Sieber, S.A., Smith, J., and Romo, D.*, "A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat Hybrids",
Bioorg. Med. Chem., doi

Rossetti, L.*, Kuntz, L.A.*, Kunold, E., Schock, J., Müller, K.W., Grabmayr, H., Stolberg-Stolberg, J., Pfeiffer, F., Sieber, S.A., Burgkart, R.*, Bausch, A.R.*, "The microstructure and micromechanics of the tendon-bone insertion", 
Nat. Mater., doi


Lehmann, J., Richers, J., Pöthig, A., Sieber, S.A.*, "Synthesis of Ramariolide Natural Products and Discovery of their Targets in Mycobacteria", 
Chem. Commun.doi

Balogh, D.*, Dahmen, M.*, Stahl, M., Poreba, M., Gersch, M., Drag, M., Sieber S.A.*, "Insights into ClpXP proteolysis: Heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes", 
Chem. Sci., doi

Kleiner, P.*, Heydenreuter, W.*, Stahl, M.*, Korotkov, V.S., Sieber S.A.*, "A whole proteome inventory of background photocrosslinker binding", 
Angew. Chem. Int. Edit., doi

Kaiser, F., Schmidt, A., Heydenreuter, W., Altmann, P.J., Casini, A., Sieber S.A., Kühn, F.E., "Self-assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity", 
Eur. J. Inorg. Chem. doi

Mandl, F.A.*, Kirsch, V.C.*, Ugur, I., Kunold, E., Vomacka, J., Fetzer, C., Schneider, S., Richter, K., Fuchs, T.M., Antes, I., Sieber S.A.*, "Natural product inspired amino-epoxybenzoquinones kill members of the gram-negative pathogen Salmonella by attenuating cellular stress response", 
Angew. Chem. Int. Edit. doi

Krysiak, J., and Sieber, S.A., "Activity-Based Protein Profiling in Bacteria", 
Meth. Mol. Bio. doi

Zhao, W., Lorenz, N., Jung, K., and Sieber, S.A., "Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action", 
Chem. Commun. doi

Bolz, C., Bach, N.C., Meyer, H., Müller, G., Dawidowski, M., Popowicz, G., Sieber, S.A., Skerra, A., Gerhard, M., "Comparison of enzymatic properties and small molecule inhibition of ɣ–glutamyltranspeptidases from pathogenic and commensal bacteria", 
Biol. Chem. doi

Javaheri, A., Kruse, T., Moonens, K., Mejías-Luque, R., Debraekeleer, A., Asche, C., Tegtmeyer, N., Kalali, B., Bach, N.C., Sieber, S.A., Hill, D., Koeniger, V., Hauck, C., Moskalenko, R., Haas, R., Busch, D., Klaile, E., Slevogt, H., Schmidt, A., Backert, S., Remaut, H., Singer, B., Gerhard, M., "Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs", 
Nature Microbiology. doi

Lehmann, J.*, Vomacka, J.*,Esser, K.*, Nodwell, M., Kolbe, K., Rämer, P., Protzer, U., Reiling, N.*, Sieber, S.A.*, "Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases",
Med. Chem. Commun. doi

Wright, M.H.*, Sieber S.A., "Chemical proteomics approaches for identifying the cellular targets of natural products",
Nat. Prod. Rep. doi

Kirmeier, T.*, Gopalakrishnan, R.*, Gormanns, V.*, Werner, A.M., Cuboni, S., Rudolf, G.C., Höfner, G., Wanner, K.T., Sieber, S.A., Schmidt, U., Holsboer, F., Rein, T.*, Hausch, F.*, "Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores",

Lehmann, J., Wright, M.H., Sieber, S.A.*, "Making a long journey short - alkyne functionalization of natural product scaffolds",
Chemistry - A European Journal doi

Gersch, M.*, Stahl, M.*, Poreba, M.*, Dahmen, M., Dziedzic, A., Drag, M.*, Sieber, S.A.*, "Barrel-shaped ClpP proteases display attenuated cleavage specificities",
ACS Chemical Biology doi

Vomacka, J., Korotkov, V.S., Bauer, B., Weinandy, F., Kunzmann, M.H., Krysiak, J., Baron, O., Böttcher, T., Lorenz-Baath, K., Sieber, S.A.*, "An aromatic hydroxyamide attenuates multiresistant Staphylococcus aureus toxin expression",
Chemistry - A European Journal doi

Zhao, W., Lorenz, N., Jung, K., Sieber, S.A.*, "Fimbrolide natural products disrupt bioluminescence of Vibrio by targeting autoinducer biosynthesis and luciferase activity",
Angew. Chem. Int. Ed. doi


Pahl, A.*, Lakemeyer, M.*, Vielberg, M.-T.*, Hackl, M.W., Vomacka, J., Korotkov, V.S., Stein, M., Fetzer, C., Lorenz-Baath, K., Richter, K., Waldmann, H., Groll, M.*, Sieber, S.A.*, "Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association",
Angew. Chem. Int. Ed. doi

Heydenreuter, W., Kunold, E., Sieber, S.A., "Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site",
Chem. Commun. doi

Koch, M.F.*, Harteis, S.*, Blank, I.D., Pestel, G., Tietze, L.F., Ochsenfeld, C., Schneider, S.*, and Sieber, S.A.*, "Structural, biochemical and computational studies reveal the mechanism of selective aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogs",
Angew. Chem. Int. Ed. doi

Hackl, M.W.*, Lakemeyer, M.*, Dahmen, M., Glaser, M., Pahl, A., Lorenz-Baath, K., Menzel, T., Sievers, S., Böttcher, T., Antes, I., Waldmann, H., Sieber, S.A., "Phenyl esters are potent inhibitors of caseinolytic protease P and reveal a stereogenic switch for de-oligomerization",
J. Am. Chem. Soc. doi

Wiedemann, E.N.*, Mandl, F.A.*, Blank, I.D.*, Ochsenfeld,C. , Ofial, A.R, Sieber, S.A., "Kinetic and theoretical studies of beta-lactone reactivity – a quantitative scale for biological application",
ChemPlusChem doi

Gersch, M.*, Famulla, K.*, Dahmen M., Göbl, C., Malik, I., Richter, K., Korotkov, V.S., Sass, P., Rübsamen-Schaeff, H., Madl, T., Brötz-Oesterhelt, H., Sieber, S.A., "AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control",
Nature Communications doi

Dahmen, M.*, Vielberg, M.-T.*, Groll, M., Sieber, S.A., "Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes",
Angew. Chem. Int. Ed. doi

Gersch, M., Hackl, M., Dubiella, C., Dobrinevski, A., Groll, M., Sieber S.A., "Intact protein mass spectrometry of 20S proteasomes reveals complex integrity, phosphorylation stoichiometry and inhibitor specificity",
Chemistry & Biology doi


Artola, M., Ruiz-Avila, L.B., Vergoñós, A., Huecas, S., Araujo-Bazán, L., Martín-Fontecha, M., Vázquez-Villa, H., Turrado, C., Ramírez-Aportela, E., Hoegl, A., Nodwell, M., Barasoain, I., Chacón, P., Sieber, S.A., Andreu, J.M., López-Rodríguez, M.L., "Effective GTP-replacing FtsZ Inhibitors and Antibacterial Mechanism of Action",
ACS Chemical Biology doi

Rudolf*, G.C., Koch*, M.F., Mandl, F.A.M., Sieber, S.A., "Subclass-Specific Labeling of Protein-Reactive Natural Products with Customized Nucleophilic Probes",
Chemistry - A European Journal doi

Harvey, N.L., Krysiak, J., Chamni, S., Cho, S.W., Sieber, S.A., Romo, D., "Synthesis of (±)-Spongiolactone Enabling Discovery of a More Potent Derivative",
Chemistry - A European Journal doi

Kreuzer, J., Bach, N.C., Forler, D., Sieber, S.A., "Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition",
Chem. Sci. doi

Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krüger, A., Liskamp, R.M.J., Groll, M., "Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site",
Angew. Chem. doi

Eirich, J., Braig, S., Schyschka, L., Servatius, P., Hoffmann, J., Hecht, S., Fulda, S., Zahler, S., Antes, I., Kazmaier, U., Sieber, S.A.*, Vollmar, A.M.*, "A small molecule protein disulfide inhibitor triggers chemosensitization of cancer cells",
Angew. Chem. doi

Wüstner, F., Mejías-Luque, R., Koch, M., Rath, E., Vieth, M., Sieber, S.A., Haller, D., Gerhard, M., "H. pylori γ-glutamyltranspeptidase impairs T lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression",
Cellular Microbiology doi

Nodwell, M. B., Koch, M. F., Alte, F., Schneider, S., Sieber, S. A., "A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage",
J. Am. Chem. Soc. doi

Weinandy, F., Lorenz-Baath, K., Korotkov, V. S., Böttcher, T., Sethi, S., Chakraborty, T., Sieber, S. A., "A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice",
ChemMedChem, 2014. doi

Kunzmann, M. H., Bach, N. C., Bauer, B., Sieber, S. A., "α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation",
Chem. Sci., 2014. doi

Kolb, R., Bach, N.C., Sieber, S.A., "β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues",
ChemComm, 2014. doi

Gersch, M., Kolb, R., Alte, F., Groll, M., Sieber, S.A., "Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition",
J. Am. Chem. Soc., 2014. doi

List*, A., Zeiler*, E., Gallastegui, N., Rusch, M., Hedberg, C., Sieber, S.A., Groll, M., "Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences",
Angew. Chem., 2014. doi


Rudolf, G.C., Sieber, S.A., "Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application",
ChemBioChem, 2013. doi

Wolf, E., Zeißler, A., Vosyka O., Zeiler E., Sieber S.A., Verhelst S.H.L., "A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization",
PLOS ONE, 2013, 8(8), e72307. doi

Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Poreba, M., Drag, M., Groll*, M., Sieber*, S.A., "Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad",
Proc. Natl. Acad. Sci. USA, 2013, 110(28), 11302-11307. doi

Wirth, T., Pestel, G.F., Ganal, V., Kirmeier, T., Schuberth, I., Rein, T., Tietze*, L.F., Sieber*, S.A., "The two faces of potent antitumor duocarmycin based drugs: A structural dissection reveals disparate motifs for DNA versus ALDH1A1 affinity",
Angew. Chem. Int. Ed. 2013, 52(27), 6921–6925. doi

Gersch, M., Gut, F., Korotkov, V., Lehmann, J., Böttcher, T., Rusch, M., Hedberg, C., Waldmann, H., Klebe, G., Sieber, S.A., "The Mechanism of Caseinolytic Protease (ClpP) Inhibition",
Angew. Chem. Int. Ed. 2013, 52, 3009-3014. doi


Rudolf, G.C., Heydenreuter, W., Sieber*, S.A., "Chemical proteomics: ligation and cleavage of protein modifications",
Current Opinion in Chemical Biology 2012, 17(1), 110-117. doi

Battenberg, O.A., Yang, Y., Verhelst, S.H.L., Sieber*, S.A., "Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification",
Mol. BioSyst. 2012, 9, 343-351. doi

Zhang, Y., Madl, T., Bagdiul, I., Kern, T., Kang, H.-S., Zou, P., Mäusbacher, N., Sieber, S.A., Kramer, A., Sattler*, A., "Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3′-splice site recognition",
Nucl. Acids Res. 2012, 41(2), 1343-1354. doi

Kunzmann, M., Sieber*, S.A., "Target analysis of α-alkylidene-γ-butyrolactones in uropathogenic E. coli",
Mol. BioSyst. 2012, 8, 3061-3067. doi

Lorenz-Baath, K., Korotkov, V., Sieber*, S.A., "In vitro percutaneous absorption of 14C-labeled beta-lactone promises topical delivery of new bacterial virulence inhibitors",
Chem. Med. Chem. 2012, 7 (8), 1490-1495. doi

Eirich, J., Burkhart, J.L., Ullrich, A., Rudolf, G.C., Vollmar, A., Zahler, S., Kazmaier*, U., Sieber*, S.A., "Pretubulysin derived probes as novel tools for monitoring the microtubule network via Activity-Based Protein Profiling and Fluorescence Microscopy",
Mol. Bio. Sys. 2012, 8, 2067-2075. doi

Nodwell, M.B., Menz, H., Kirsch, S.F., Sieber*, S.A., "Rugulactone and its Analogues Exert Antibacterial Effect Through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis",
Chem. Bio. Chem. 2012, 13 (10), 1439-1446. doi

Krysiak, J.M., Kreuzer, J., Macheroux, P., Hermetter, A., Sieber*, S.A., Breinbauer*, R., "Novel activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of MAO-inhibitors",
Angew. Chem. 2012, 51 (28), 7035-7040. doi

Pitscheider, M., Mäusbacher, N., Sieber*, S.A., “Antibiotic activity and target discovery of three-membered natural product-derived heterocycles in pathogenic bacteria”,
Chem. Sci., 2012, 3, 2035-2041. doi

Gersch, M., Kreuzer, J., Sieber*, S.A., "Electrophilic natural products and their biological targets",
Nat. Prod. Rep., 2012, 29, 659-682. doi.

Gersch, M., List, A., Groll, M., Sieber*, S.A., "Insights into the structural network responsible for oligomerization and activity of the bacterial virulence regulator caseinolytic protease P (ClpP)",
J. Biol. Chem., 2012, 287 (12), 9484-9494. doi

Wirth, T., Schmuck, K., Tietze, L.F., Sieber*, S.A., "Novel mode of action: Duocarmycin analogs target aldehyde dehydrogenase1 in lung cancer cells",
Angew. Chem. Int. Ed., 2012, 51 (12), 2874-2877. doi

Boettcher, T., Sieber*, S.A., "β-Lactams and β-lactones as activity-based probes in chemical biology"
Med. Chem. Commun., 2012, 3, 408-417. doi


Nodwell, M.B., Sieber*, S.A., "ABPP Methodology: Introduction and Overview"
Topics in Current Chemistry, 2011, 1-41. doi

Zeiler, E., Braun, N., Böttcher, T., Kastenmüller, A., Weinkauf, S., Sieber*, S.A., "Vibralactone as a tool to unravel the activity and structure of the Listeria monocytogenes ClpP1P2 complex"
Angew. Chem. Int. Ed., 2011,50 (46), 11001-11004. doi

Zeiler, E., Korotkov, V.S., Lorenz-Baath, K., Böttcher, T., Sieber*, S.A., "Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP"
Bioorg. Med. Chem., 2011, 20 (2), 583-591. doi

Rusch, M., Zimmermann, T.J., Bürger, M., Dekker, F.J., Görmer, K., Triola, G., Brockmeyer, A., Janning, P., Böttcher, T., Sieber, S.A., Vetter, I.R., Hedberg*, C., Waldmann*, H., "Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signalling Modulators Palmostatin B and M"
Angew. Chem. Int. Ed., 2011, 123 (42), 10006-10011. doi

Globisch, D., Pearson, D., Hienzsch, A., Brückl, T., Wagner, M., Thoma, I., Thumbs, P., Reiter, V., Kneuttinger, A.-C., Müller, M., Sieber, S.A., Carell*, T., "Systems-Based Analysis of Modified tRNA Bases"
Angew. Chem. Int. Ed., 2011, 50 (41), 9739-9742. doi

Eirich, J., Orth, R., Sieber*, S.A., "Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells"
J. Am. Chem. Soc., 2011, 133 (31), 12144-12153. doi

Battenberg, O., Nodwell, M., Sieber*, S.A., "Evaluation of alpha-pyrones and pyrimidones as photoaffinity probes for affinity based protein profiling"
J. Org. Chem., 2011, 76 (15), 6075-6087. doi

Geiger, S.R., Böttcher, T., Sieber*, S.A. and Cramer*, P., "A conformational switch underlies ClpP protease function"
Angew. Chem. Int. Ed., 2011, 50 (25), 5749-5752. doi

Kunzmann, M.H., Staub, I., Böttcher, T. and Sieber, S.A., "Protein Reactivity of Natural Product-Derived y-Butyrolactones"
Biochem., 2011, 50 (5), 910-916. doi


Gersch, M., Sieber, S.A., "Disarming Clostridium difficile"
Chemistry & Biology, 2010, 17, 1165-1166. doi

Orth, R., Böttcher, T. and Sieber, S.A., "The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds"
ChemComm, 2010, 46, 8475-8477. doi

Rathore, S., Sinha, D., Asad, M., Böttcher, T., Afreen, F., Chauhan, V. S., Gupta, D., Sieber, S. A., Mohmmed, A., "A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development"
Mol. Microbiol, 2010, 77 (4), 873–890. doi

Orth, R., Pitscheider, M. and Sieber, S.A., "Chemical probes for the labeling of the bacterial glucosaminidase NagZ via the Huisgen cycloaddition"
Synthesis, 2010, (13), 2201–2206. doi

Böttcher, T.; Sieber, S.A., “Showdomycin as a versatile chemical tool for the detection of pathogenesis associated enzymes in bacteria”
J. Am. Chem. Soc., 2010, 132 (20), 6964–6972. doi

Böttcher, T., Pitscheider, M. and Sieber, S.A., “Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies”
Angewandte Chemie, 2010, 49 (15), 2680–2698. doi

Sieber, S.A.; Böttcher, T.; Staub, I.; Orth, R., “Comprehensive Natural Products II: Chemistry and Biology”,
Elsevier Science & Technology, ISBN: 978-0080453811.


Orth, R., Sieber, S. A., “A photolabile linker for the mild and selective cleavage of enriched biomolecules from solid support”
J. Org. Chem., 2009, 74 (21), 8476–8479. doi

Pitscheider, M., Sieber, S. A., “Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes”
Chem. Comm., 2009, 3741–3743. doi

Böttcher, T., and Sieber, S. A., “beta-Lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages”
ChemMedChem, 2009, 4, 1260–1263. doi

Staub, I., and Sieber, S. A., "beta-Lactam probes as selective chemical-proteomic tools for the identification and functional characterization of resistance associated enzymes in MRSA"
J. Am. Chem. Soc., 2009, 131, 6271–6276. doi

Sieber, S. A., “Unraveling the secrets of protein-metabolite interactions”
ChemBioChem, 2009, 10, 799–801. doi

Böttcher, T., Sieber, S. A., “Structurally Refined β-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors”
ChemBioChem, 2009, 10, 663–666. doi


Böttcher, T., Sieber, S. A., “beta-Lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus”
J. Am. Chem. Soc., 2008, 130, 14400–14401. doi

Staub, I., and Sieber, S. A., "beta-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence"
J. Am. Chem. Soc., 2008, 130, 13400–13407. doi

Böttcher, T., and Sieber, S. A., "beta-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes"
Angewandte Chemie, 2008, 47, 4600–4603. doi

S. A. Sieber, T. Böttcher, 2008, “Sensitive und selektive Inhibition von bakteriellen Virulenzfaktoren in lebenden Zellen mittels beta-Lacton Molekülen. Neue Angriffsziele für Antibiotika“. Europäische Patentanmeldung.


Sieber, S. A., Niessen, S., Hoover, H. S., Cravatt, B. F., "Proteomic Profiling of Metalloproteases with Cocktails of Active-Site Directed Probes"
Nature Chemical Biology 2006, 5, 274–281.

Sieber, S. A., Cravatt, B. F., "Analytical Platforms for Activity-Based Protein Profiling: the Versatility of Chemistry Applied to Functional Proteomics"
Chemical Communications 2006, 22, 2311–2319.

Balakrishnan, A., Patel, B., Sieber, S. A., Pachikara, N., Zhong, G., Cravatt, B. F., Fan, H., “Metalloprotease Inhibitors GM6001 and TAPI-0 Inhibit the Obligate Intracellular Human Pathogen Chlamydia trachomatis by Targeting Polypeptide Deformylase of the Bacterium”
J. Biol. Chem. 2006, 281, 16691–16699.

Wagner, B., Sieber, S. A., Baumann, M., Marahiel, M. A., “Solvent Engineering Substantially Enhances the Chemoenzymatic Production of Surfaction“
ChemBioChem. 2006, 4, 595–587.


Grünewald, J., Kopp, F., Mahlert, C., Linne, U., Sieber, S. A., Marahiel, M. A. “Fluorescence Resonance Energy Transfer as a Probe of Peptide Cyclization by Nonribosomal Thioesterase Domains“
Chem. & Biol. 2005, 8, 873–881.

Mahlert C., Sieber, S. A., Grünewald, J., Marahiel, M. A. “Chemoenzymatic Approach to Enantiopure Streptogramin B Variants: Characterization of Stereoselective Pristinamycin I Cyclase from Streptomyces Pristinaespiralis“
J. Am. Chem. Soc. 2005, 127, 9571–9580.

Sieber, S. A., Marahiel, M. A. “ Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics”
Chemical Reviews. 2005, 105, 715–738.


Sieber, S. A., Mondala, T. S., Head, S. R., Cravatt, B. F. “Microarray Platform for Profiling Enzyme Activities in Complex Proteomes”
J. Am. Chem. Soc. 2004, 126, 15640–15641.

Grünewald, J., Sieber, S. A., Mahlert, C., Linne, U., Marahiel, M. A. “Synthesis and Derivatization of Daptomycin: A Chemoenzymatic Route to Novel Acidic Lipopeptide Antibiotics”
J. Am. Chem. Soc. 2004, 126, 17025–17031.

Garbe, D., Sieber, S. A., Bandur, N., Koert, U., Marahiel, M. A. “Enzymatic Cyclization of Peptidomimetics with incorporated (E)-Alkene-Dipeptideisosteres“
ChemBioChem. 2004, 5, 1000–1003.

Grünewald, J.*, Sieber, S. A.*, Marahiel, M. A. “ Chemo- and Regioselective Peptide Cyclization triggered by the N-terminal Fatty Acid Chain Length: The Recombinant Cyclase of the Calcium-dependent Antibiotic from Streptomyces coelicolor”
Biochemistry. 2004, 43 2915–2925.

Sieber, S. A., Tao, J., Walsh, C. T., Marahiel, M. A. “Peptidyl thiophenols as substrates for nonribosomal peptide cyclases “.
Angewandte Chemie. 2004, 116, 449–504.


Sieber, S. A., Marahiel, M. A. “Learning from Nature´s drug factories: Nonribosomal Synthesis of cyclic peptides”
J. Bacteriol. 2003, 185, 7036–7043.

Clugston, S. L., Sieber, S. A., Marahiel, M. A., Walsh, C. T. “Chirality of peptide-bond forming condensation domains in nonribosomal peptide synthetases: The C5 domain of tyrocidine synthetase is a DCL catalyst”
Biochemistry. 2003, 42, 12095–12104.

Sieber, S. A., Walsh, C. T., Marahiel, M. A. “Loading peptidyl-coemzyme A onto peptidyl carrier proteins – a novel approach in characterizing macrocyclization by thioesterase domains”
J. Am. Chem. Soc. 2003, 125, 10862–10866.

Sieber, S. A., Marahiel, M. A. “Antibiotika vom molekularen Fließband: Modulare Peptidsynthetasen als Biokatalysatoren“
Biospektrum, 2003, Sonderausgabe, 9. Jahrgang.

M. A. Marahiel, S. A. Sieber, 2003, “Verfahren zur Herstellung zyklischer Moleküle“. Deutsche Patenturkunde DE 103 35 584 B4


Tseng, C. C.*, Bruner, S. D., Kholi, R. M., Marahiel, M. A., Walsh, C. T., Sieber, S. A.* “Characterization of the surfactin C-terminal thioesterase domain as a cyclic depsipeptide synthase“
Biochemistry. 2002, 41, 13350–13359.

Sieber, S. A.*, Linne, U.*, Hillson, N. J., Roche, E., Walsh, C. T., Marahiel, M. A. “Evidence for a monomeric structure of nonribosomal peptide synthetases“
Chem. & Biol., 2002, 9, 997–1008.

Edmundson, M. J., Zhou, W., Sieber, S. A., Jones, I. P., Gameson, I., Anderson, P. H., Edwards, P. P. “Electron beam induced growth of bare silver nanowires from zeolite crystallites“
Advanced Materials, 2001, 13, 1608.

*these authors contributed equally to this work or are equal corresponding authors